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自1962年至1972年共治疗滋养细胞疾患258例其中63例治疗后妊娠,占24.4％。取36例曾用化(?)的病例,并以36例葡萄胎自然流产后未用化疗者及36例产科门诊病人作为对照,以观察化疗对妊娠及胎儿之影响。36例用化疗者:4例绒癌、4例恶葡、28例组织学不清属临床诊断。化疗用氨甲喋呤、放线菌素D、6巯—基嘌呤及氮杂脲嘧啶核苷(6-Azauridine)。经详细询问病史作对比。化疗后病人妊娠分娩合并症升高:5例妊娠中毒症、1例早产、2例产后出血、2例前置胎盘、4例产钳分娩、5例剖腹产。
From 1962 to 1972 a total of 258 cases of trophoblastic disorders were treated, of which 63 cases of pregnancy after treatment, accounting for 24.4%. Thirty-six cases of patients who had been treated (?) Were enrolled in this study. 36 cases of spontaneous abortion without chemotherapy and 36 obstetric outpatients were used as controls to observe the effects of chemotherapy on pregnancy and fetus. 36 cases with chemotherapy: 4 cases of choriocarcinoma, 4 cases of evil Portuguese, 28 cases of histological diagnosis is not clear. Chemotherapy with methotrexate, actinomycin D, 6-mercaptopurine and 6-Azauridine. After detailed history for comparison. Chemotherapy patients with complications of pregnancy and childbirth increased: 5 cases of gestosis, 1 case of preterm birth, 2 cases of postpartum hemorrhage, 2 cases of placenta previa, 4 cases of forceps delivery, 5 cases of caesarean section.