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来自美国波士顿哈佛大学公共卫生学院的研究团队近期在《美国医学会杂志》(JAMA)上披露了一项研究成果,他们对取自1 517名有冠心病的2型糖尿病患者、2 671名无冠心病的乙型糖尿病患者、737名无糖尿病的冠心病患者和1 637名既无冠心病也无糖尿病的人士体内的2 543 016个突变基因样本进行检测分析、比对,从中寻找与冠心病有关的基因,结果经层层筛选,终于发现糖尿病患者的染色体1q25位点上一段突变基因与冠心病高风险相关,而无糖尿病者中未见此突变基因与冠心病有关联。鉴于此突变基因位于染色体1q25上谷氨酸-氨连接酶(GLUL)基因区域内,故推测此突变基因可能是通过减少内皮细胞中GLUL基因的表达和干扰谷氨酸及谷氨酰胺的代谢而增加冠心病风险,且此突变基因似乎与糖尿病患者发生冠心病存在特异性关联,并显示出其与糖尿病在增加冠心病风险方面具有明显的协同作用。不过,该研究团队指出,进一步剖析和确定此突变基因或糖尿病与冠心病的深层次关系及其生物机制,尚需一系列更深入的研究与实验。
A team of researchers from the Harvard School of Public Health in Boston recently disclosed a study in JAMA that evaluated 2 571 patients with type 2 diabetes who had coronary heart disease, Coronary heart disease in patients with type 2 diabetes, 737 non-diabetic patients with coronary heart disease and 1 637 who have neither coronary heart disease nor diabetes in vivo 2 543 016 mutation gene samples were detected and analyzed, compared to find and coronary heart disease Related genes, the results of the layers of screening, and finally found in patients with diabetes chromosome 1q25 mutation at a locus and coronary heart disease is associated with a high risk, but no diabetes were not found in this gene mutation associated with coronary heart disease. Given that this mutant gene is located in the glutamate-ammonia ligase (GLUL) gene region on chromosome 1q25, it is speculated that this mutant gene may be increased by reducing the GLUL gene expression in endothelial cells and interfering with glutamate and glutamine metabolism Coronary heart disease risk, and this mutant gene appears to be specifically associated with coronary heart disease in patients with diabetes, and shows its synergistic effect with diabetes in increasing the risk of coronary heart disease. However, the team pointed out that further analysis and determination of the mutant gene or diabetes and coronary heart disease, the deep relationship and its biological mechanism, still need a series of more in-depth research and experiments.