论文部分内容阅读
目的:研究SSBP1在乙肝相关性肝细胞癌(hepatocellular carcinoma,HCC)组织中的表达及其与患者临床病理特征的关系,为肝癌的诊断和预后判断提供参考依据。方法:收集血清乙肝病毒表面抗原(HBVs Ag)阳性的HCC患者组织标本216例,采用免疫组化和Western blot检测癌及癌旁组织中SSBP1的表达水平,并进行统计分析。结果:SSBP1蛋白在癌组织中的表达水平明显高于癌旁组织(P<0.05)。SSBP1表达水平与肿瘤数量、肿瘤大小、门静脉癌栓和肿瘤分级具有显著的相关性(P<0.05)。SSBP1低表达患者术后总生存期及无复发生存期明显优于SSBP1高表达的患者(P<0.05)。结论:SSBP1在HCC的发生发展过程中发挥重要作用,特对患者的预后判断具有一定的参考价值。
Objective: To investigate the expression of SSBP1 in hepatocellular carcinoma (HCC) and its relationship with clinicopathological features, and to provide a reference for the diagnosis and prognosis of hepatocellular carcinoma. METHODS: Totally 216 cases of HCC from patients with positive HBVsAg were collected. The expression of SSBP1 was detected by immunohistochemistry and Western blot, and statistical analysis was performed. Results: The expression of SSBP1 protein in cancer tissues was significantly higher than that in adjacent tissues (P <0.05). The expression level of SSBP1 was significantly correlated with tumor number, tumor size, portal vein tumor thrombus and tumor grade (P <0.05). The overall postoperative survival and recurrence-free survival of SSBP1 patients with low expression were significantly better than those with high SSBP1 expression (P <0.05). Conclusion: SSBP1 plays an important role in the occurrence and development of HCC, and has certain reference value for the prognosis of patients.