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目的探讨硫酸软骨素对软骨细胞增殖影响的作用机制及其在耳硬化症防治上的应用前景。方法用硝基四氮唑蓝法研究硫酸软骨素对体外培养兔软骨细胞琥珀酸脱氢酶（ＳＤＨ）活性的影响。结果对照组与实验组ＳＤＨ活性无明显差异，即加入或不加入硫酸软骨素的兔软骨培养细胞内ＳＤＨ活性无明显改变（Ｐ＞０．０５）。结论硫酸软骨素有望用于治疗耳硬化症
Objective To explore the mechanism of chondroitin sulfate on the proliferation of chondrocytes and its application in the prevention and treatment of otosclerosis. Methods Nitroblue tetrazolium blue method was used to study the effect of chondroitin sulfate on the activity of succinate dehydrogenase (SDH) in cultured rabbit chondrocytes. Results There was no significant difference in SDH activity between the control group and experimental group. SDH activity in rabbit chondrocytes cultured with or without chondroitin sulfate had no significant change (P> 0.05). Conclusion Chondroitin sulfate is expected to be used to treat otosclerosis