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目的:评价血清CA15-3水平及其倍增时间(DT)对18F-FDG SPECT/CT探测乳腺癌患者术后复发及转移的影响。方法:对43例乳腺癌术后患者进行18F-FDG SPECT/CT显像,每位患者均接受>2次的血清肿瘤标志CA15-3测定,并计算其倍增时间。结果:根据病理检查结果或>1年的临床随访,43例患者中有21例最终诊断为复发或转移。按患者例数计算,18F-FDG SPECT/CT的灵敏度、特异度、准确度、阳性预测值和阴性预测值分别为86%、64%、74%、69%和82%。18F-FDG SPECT/CT显像阳性患者的血清CA15-3水平高于18F-FDGSPECT/CT显像阴性患者,结果差异有统计学意义,P<0.05;0 d180 d及DT<0的患者18F-FDG SPECT/CT阳性率与阴性率差异无统计学意义,P>0.05。结论:对于血清CA15-3水平升高或其倍增时间较短的乳腺癌术后患者,进行18F-FDG SPECT/CT显像探测复发或转移的价值更大。
Objective: To evaluate the effect of serum CA15-3 level and doubling time (DT) on the detection of 18F-FDG SPECT / CT in detecting the recurrence and metastasis of breast cancer patients. Methods: Forty-three postoperative patients with breast cancer underwent 18F-FDG SPECT / CT imaging. Each patient received serum tumor marker CA15-3> 2 times and their doubling time was calculated. Results: Based on the results of the pathological examination or> 1 year of clinical follow-up, 21 of the 43 patients were eventually diagnosed as recurrent or metastatic. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of 18F-FDG SPECT / CT were 86%, 64%, 74%, 69% and 82%, respectively. The level of serum CA15-3 in patients with positive 18F-FDG SPECT / CT imaging was higher than that in patients with negative 18F-FDGSPECT / CT imaging, the difference was statistically significant, P <0.05; 18F- FDG SPECT / CT positive rate than the negative rate, the difference was statistically significant, P <0.05; DT> 180 d and DT <0 of 18F-FDG SPECT / CT positive rate and negative rate was not statistically significant, P> 0.05. CONCLUSIONS: 18F-FDG SPECT / CT imaging is more valuable for detection of recurrence or metastasis in postoperative breast cancer patients with elevated serum levels of CA15-3 or shorter doubling times.