采用放射免疫方法检测73例新生儿缺氧缺血性脑病(HIE)和71例正常新生儿出生后第1天、第3天、第5天空腹血清胃泌素值的变化.其平均值分别为95.03±36.93ng/L;213.75±65.75ng/L,差异显著(P<0.01).两者不同日龄血清胃泌素值对照比较,结果表明,HIE患儿血清胃泌素浓度明显高于正常新生儿,经统计学处理P<0.01。提示HIE患儿有高胃泌素血症存在,在防治过程中应注意重视保护胃肠粘膜,从而减少胃肠道并发症发生. Radioimmunoassay was used to detect the changes of fasting serum gastrin levels in 73 neonates with hypoxic-ischemic encephalopathy (HIE) and 71 normal neonates at postnatal days 1, 3 and 5. The mean values ​​were (95.03 ± 36.93ng / L, 213.75 ± 65.75ng / L), the difference was significant (P <0.01) .The serum gastrin levels of the two groups were compared at different days, the results showed that the serum gastrin concentration in HIE children was significantly higher than Normal newborn, the statistical analysis of P <0.01. Prompt HIE children with hypergastrinemia exist in the prevention and treatment process should pay attention to the protection of gastrointestinal mucosa, thereby reducing the incidence of gastrointestinal complications.