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目的：观察地奥心血康（ＤＡＸＸＫ）对犬心肌缺血再灌注的血液ＬＰＯ，氧自由基及红细胞ＳＯＤ的影响。方法：１８只成年杂种犬复制心肌缺血再灌注模型，分为ＤＡＸＸＫ治疗组和０．９％氯化钠注射液对照组。以荧光法测定血液ＬＰＯ；电子自旋共振（ＥＳＲ）行全血氧自由基捕捉；ＮＢＴ比色法测定红细胞及心肌中ＳＯＤ活力。结果：ＤＡＸＸＫ组血中ＬＰＯ含量低于对照组（Ｐ＜０．０５）；红细胞及心肌ＳＯＤ活力高于对照组（Ｐ＜０．０５，Ｐ＜０．０１）；对照组冠脉血中有强的氧自由基信号出现，而ＤＡＸＸＫ组的ＥＳＲ谱中氧自由基信号消失。结论：ＤＡＸＸＫ有降低心肌缺血再灌犬血中ＬＰＯ、氧自由基、提高红细胞及心肌ＳＯＤ活力的作用。
Objective: To observe the effects of DAXXK on blood LPO, oxygen free radicals and erythrocyte SOD in myocardial ischemia-reperfusion dogs. Methods: 18 adult mongrel dogs were randomly divided into DAXXK treatment group and 0.9% sodium chloride injection control group. Blood LPO was measured by fluorescence method; whole blood oxygen free radical trapping was performed by electron spin resonance (ESR); SOD activity in erythrocytes and myocardium was measured by NBT colorimetry. Results: The level of LPO in DAXXK group was lower than that in control group (P <0.05). The activity of SOD in erythrocyte and myocardium was higher than that in control group (P <0.05, P <0.01) Strong oxygen free radical signal appears, but DAXXK group ESR spectrum oxygen free radical signal disappears. Conclusion: DAXXK can reduce LPO and oxygen free radicals in canine ischemia-reperfusion dogs and increase the activity of SOD in erythrocytes and myocardium.