论文部分内容阅读
目的对FP与TP序贯放疗治疗中晚期食管癌的进行疗效观察。方法入组32例,随机分为两组,第1周期化疗结束后开始放疗,放疗结束后开始第2周期化疗。放疗采用三维适形放疗,总量至60~70Gy。共行4~6周期化疗。结果 FP组总有效率78.6%,TP组总有效率77.7%。两组的有效率差异无统计学意义(χ2=0.142,P>0.05),TP组的Ⅲ/Ⅳ度血液学毒性发生率高于FP组。结论两种方案序贯三维适形放疗的有效率相似,TP方案的Ⅲ~Ⅳ度骨髓抑制的发生率高于FP方案。
Objective To observe the curative effect of FP and TP sequential radiotherapy on advanced esophageal cancer. Methods 32 cases were enrolled and randomly divided into two groups. After the first cycle of chemotherapy, radiotherapy was started and the second cycle of chemotherapy was started after the end of radiotherapy. Radiotherapy using three-dimensional conformal radiotherapy, the total to 60 ~ 70Gy. A total of 4 to 6 cycles of chemotherapy. Results The total effective rate was 78.6% in FP group and 77.7% in TP group. There was no significant difference in the effective rate between the two groups (χ2 = 0.142, P> 0.05). The incidence of grade Ⅲ / Ⅳ hematologic toxicity in TP group was higher than that in FP group. Conclusions The two kinds of sequential three-dimensional conformal radiotherapy have similar efficacies. The incidence of grade Ⅲ ~ Ⅳ myelosuppression in TP regimen is higher than that in FP regimen.