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目的观察阿奇霉素和IFN-γ联用治疗小鼠弓形虫病的效果及小鼠体内细胞免疫功能的变化。方法将100只BALB/c小鼠随机分为感染对照组(A组)、阿奇霉素治疗组(B组)、阿奇霉素和IFN-γ治疗组(C组)、IFN-γ治疗组(D组)及空白对照组(E组)5组。A、B、C、D组均用弓形虫速殖子腹腔感染小鼠。B、C、D组于感染后24 h给药,连续5 d,观察10 d内小鼠的平均存活时间。同时在感染后第2、3、5天取小鼠尾静脉血测其CD4+、CD8+T细胞水平。结果C组小鼠存活时间明显延长,各时段CD4+T细胞水平均显著升高,CD8+T细胞水平显著降低,CD4+与CD8+T细胞比值明显升高。结论阿奇霉素和IFN-γ联用可提高小鼠弓形虫病的治疗效果,改善弓形虫感染后小鼠体内的细胞免疫功能。
Objective To observe the effect of azithromycin combined with IFN-γ in the treatment of toxoplasmosis in mice and the changes of cellular immune function in mice. Methods 100 BALB / c mice were randomly divided into infection control group (A group), azithromycin treatment group (B group), azithromycin and IFN-γ treatment group (C group), IFN-γ treatment group Blank control group (E group) 5 groups. Mice were infected with T. gondii tachyzoites intraperitoneally in groups A, B, C and D, respectively. Groups B, C and D were administered 24 h after infection for 5 consecutive days. The mean survival time of mice in 10 d was observed. At the same time, the tail vein blood was collected to detect the levels of CD4 + and CD8 + T cells on days 2, 3 and 5 after infection. Results The survival time of mice in group C was significantly prolonged. The levels of CD4 + T cells in each group were significantly increased, the levels of CD8 + T cells were significantly decreased, and the ratio of CD4 + to CD8 + T cells was significantly increased. Conclusion The combination of azithromycin and IFN-γ can improve the therapeutic effect of Toxoplasma gondii in mice and improve the cellular immune function in mice after Toxoplasma gondii infection.