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目的：研究小儿原发性肾病综合征（ＰＮＳ）Ｔａｍｍ－Ｈｏｒｓｆａｌ蛋白（ＴＨＰ）与β２微球蛋白（β２ＭＧ）水平改变的意义。方法：对小儿ＰＮＳ６０例活动期和缓解期血ＴＨＰ、β２ＭＧ水平和尿ＴＨＰ、β２ＭＧ排泄量进行测定。结果：血ＴＨＰ、β２ＭＧ值均在正常范围。尿ＴＨＰ排泄量持续增高，且以激素治疗耐药和依赖者增高为著。β２ＭＧ排泄ＰＮＳ－Ｉ完全正常；ＰＮＳ－Ⅱ活动期增高，缓解期恢复正常；ＰＮＳ－Ⅲ持续增高。肾合成ＴＨＰ功能增强，原因不明。尿β２ＭＧ排泄增多可能系近曲小管功能受损所致。结论：ＴＨＰ和β２－ＭＧ水平改变对ＰＮＳ有重要意义
Objective: To investigate the significance of Tamm-Horsfal protein (THP) and β2 microglobulin (β2MG) in children with primary nephrotic syndrome (PNS). Methods: The levels of THP, β2MG and urinary THP, β2MG excretion in 60 children with PNS during active and remission period were measured. Results: Blood THP, β2MG values were in the normal range. Urinary THP excretion continued to increase, and the resistance to hormone therapy and increased dependence on. β2MG excretion PNS-I completely normal; PNS-Ⅱ activity increased, the remission returned to normal; PNS-Ⅲ continued to increase. Increased renal synthesis of THP for unknown reasons. Increased urine β2MG excretion may be caused by damage to proximal tubule function. Conclusion: The changes of THP and β2-MG levels are of great significance to PNS