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目的:探讨Bcl-2、PTEN在子宫内膜癌组织中的表达及相关情况。方法:采用免疫组化SP法检测50例子宫内膜癌、20例正常子宫内膜组织中Bcl-2、PTEN蛋白的表达。结果:①正常子宫内膜组织中Bcl-2蛋白阳性表达率为90.0%,显著高于Bcl-2蛋白在子宫内膜癌组织中的阳性表达率(44.0%)(P<0.05),不同临床分期、组织分级之间其表达率比较差异均有统计学意义(P<0.05)。②PTEN在正常子宫内膜中的阳性表达率为90.0%,高于其在子宫内膜癌组织中的阳性表达率(32.0%)(P<0.05),不同临床分期、组织分级之间其表达率比较差异无统计学意义(P>0.05)。③Bcl-2、PTEN在子宫内膜癌组织中的表达有相关性(χ2=6.0883,P<0.05)。结论:在子宫内膜癌恶性进展中Bcl-2、PTEN表达下调,提示二者在子宫内膜癌的发生、发展中有协同作用。
Objective: To investigate the expression of Bcl-2 and PTEN in endometrial carcinoma and related conditions. Methods: Immunohistochemical SP method was used to detect the expression of Bcl-2 and PTEN in 50 cases of endometrial carcinoma and 20 cases of normal endometrium. Results: ① The positive rate of Bcl-2 protein in normal endometrium was 90.0%, which was significantly higher than that of Bcl-2 protein in endometrial carcinoma (44.0%) (P <0.05) There were significant differences in the expression rates between the staging and the grading (P <0.05). ② The positive expression rate of PTEN in normal endometrium was 90.0%, which was higher than that in endometrial carcinoma (32.0%) (P <0.05). The expression rate of PTEN between different clinical stages and histological grade The difference was not statistically significant (P> 0.05). The expression of Bcl-2, PTEN in endometrial carcinoma was correlated (χ2 = 6.0883, P <0.05). Conclusion: The down-regulation of Bcl-2 and PTEN expression in the malignant progression of endometrial carcinoma suggests that both of them have a synergistic effect on the occurrence and development of endometrial carcinoma.