论文部分内容阅读
胸腺移植主要用于治疗各类原发及继发性免疫缺陷病。移植形式有组织直接移植和培养上皮细胞移植二种,本文对后一种形式进行了研究,并在临床应用上作了初步的探索。胸腺上皮细胞取自引产胎儿胸腺,体外培养14天左右,经细胞形态及遗传学分析表明符合移植要求,用上述培养细胞先后移植3例儿科病人。患儿均系临床上长期反复感染,用抗生素及普通生物制品难以奏效。移植结果表明,所有患者在近期内均未发生对植入细胞的排异反应,2个月至半年内随访,临床表现和有关免疫指标都有不同程度改善,实际应用表明,培养胸腺上皮细胞移植基本无副反应,且操作简便,可以成为一种新的免疫治疗方法。
Thymus transplantation is mainly used for the treatment of various types of primary and secondary immune deficiency disease. Transplantation of the form of direct transplantation of tissue culture and epithelial cell transplantation in two, this article on the latter form has been studied and made a preliminary exploration in clinical application. Thymus epithelial cells were taken from the thymus of fetus fetus and cultured in vitro for about 14 days. The morphological and genetic analysis showed that the thymus epithelial cells met the transplantation requirements. Three pediatric patients were transplanted with the cultured cells. Children are clinically long-term repeated infections, with antibiotics and common biological products difficult to work. Transplantation results show that all patients in the near future did not occur on the rejection of implanted cells, 2 months to six months follow-up, clinical manifestations and related immune indicators have varying degrees of improvement, the practical application shows that the culture of thymic epithelial cell transplantation Basic side effects, and easy to operate, can become a new immunotherapy.