论文部分内容阅读
目的探究大剂量丙种球蛋白联合阿司匹林治疗小儿川崎病的临床效果。方法回顾性选取2015年9月至2016年9月收治的75例川崎病患儿临床资料进行分析,将其分为对照组(35例)与研究组(40例),对照组予以阿司匹林单药治疗,研究组在对照组基础联合大剂量丙种球蛋白治疗,比较两组临床指标变化情况以及肿瘤坏死因子(Tn F-α)、超敏C反应蛋白(hs-CRP)水平变化。结果研究组黏膜充血消失、退热、颈淋巴肿大消退与手足肿胀消退时间均短于对照组(P<0.05),研究组Tn F-α、hs-CRP水平均较对照组低(P<0.05)。结论小儿川崎病予以大剂量丙种球蛋白及阿司匹林联合治疗能够有效改善患儿临床症状,提高治疗效果,具临床推广价值。
Objective To investigate the clinical effect of high-dose gamma globulin combined with aspirin in children with Kawasaki disease. Methods The clinical data of 75 children with Kawasaki disease admitted from September 2015 to September 2016 were retrospectively analyzed. They were divided into control group (35 cases) and study group (40 cases), while those in control group were given aspirin monotherapy After treatment, the study group was treated with high-dose gamma globulin in the control group. The changes of clinical indexes and the levels of tumor necrosis factor (TnF-α) and hs-CRP in the two groups were compared. Results The disappearance of mucosal hyperemia, fever, regression of cervical lymphadenopathy, and regression of hand and foot swelling were all shorter in the study group than in the control group (P <0.05). The levels of Tn F-α and hs-CRP in the study group were lower than those in the control group (P < 0.05). Conclusion Kawasaki disease in children given high-dose gamma globulin and aspirin combination therapy can effectively improve the clinical symptoms of children and improve the treatment effect, with clinical value.