随着杂交瘤技术的进展阳肿瘤新抗原的发现,用肿瘤细胞或相关抗原免疫小鼠的 B 细胞与骨髓瘤细胞杂交,制备出了多种单克隆抗体(简称单抗)。有些单抗国外已作为商品进入市场,为肿瘤基础和临床研究方面应用单抗提供了有利条件。其中,单抗在肿瘤诊断中的应用,就是倍受重视的课题之一。本文就此作简要介绍。 With the development of hybridoma technology, the discovery of positive tumor neoantigens, B cells from mice immunized with tumor cells or related antigens were hybridized with myeloma cells to prepare monoclonal antibodies (abbreviated as monoclonal antibodies). Some monoclonal antibodies have entered the market as commodities, providing favorable conditions for the use of monoclonal antibodies in tumor basic and clinical research. Among them, the application of monoclonal antibody in tumor diagnosis is one of the most important topics. This article gives a brief introduction to this.