【摘 要】
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Mediator, a conserved multiprotein complex in animals, plants, and fungi, is a cofactor of RNA polymerase Ⅱ (Pol Ⅱ). It is known to promote basal Pol Ⅱ-media
【机 构】
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Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of C
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Mediator, a conserved multiprotein complex in animals, plants, and fungi, is a cofactor of RNA polymerase Ⅱ (Pol Ⅱ). It is known to promote basal Pol Ⅱ-mediated transcription as well as bridge sequence-specific transcriptional regulators and Pol Ⅱ to integrate regulatory information. Pol Ⅱ transcribes not only protein-coding genes but also intergenic regions to generate noncoding RNAs such as small RNAs (microRNAs and small interfering RNAs) and long noncoding RNAs. Intriguingly, two plant-specific polymerases, Pol Ⅳ and Pol Ⅴ, have evolved from Pol Ⅱ and play a role in the production of small interfering RNAs and long noncoding RNAs at heterochromatic regions to maintain genome stability through transcriptional gene silencing (TGS). Recent studies have defined the composition of the plant Mediator and evaluated its role in noncoding RNA production in relationship to Pol Ⅱ, Pol Ⅳ and Pol Ⅴ. Here, we review the functions of Mediator and that of noncoding RNAs generated by Pol Ⅱ, Pol Ⅳ and Pol Ⅴ in plants, and discuss a role of Mediator in epigenetic regulation via noncoding RNA production.
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