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目的:观察脑活素联合高压氧治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法:2009年1月～2010年1月期间,82例HIE患儿随机分为观察组和对照组,每组41例,观察组采用脑活素联合高压氧治疗,对照组仅采用脑活素治疗,比较两组治疗方法的临床疗效及神经功能恢复情况。结果:观察组的显效率及总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后1个疗程、出生28天后NBNA评分均较治疗前明显升高,差异有统计学意义(P<0.05)。观察组治疗后1个疗程、出生28天后NBNA评分均明显高于同期对照组,两组比较差异有统计学意义(P<0.05)。结论:脑活素联合高压氧治疗HIE能够明显提高疗效,促进新生儿神经功能的恢复,值得临床推广应用。
Objective: To observe the clinical efficacy of cerebrolysin and hyperbaric oxygen in neonates with hypoxic-ischemic encephalopathy (HIE). Methods: From January 2009 to January 2010, 82 children with HIE were randomly divided into observation group and control group, 41 cases in each group. The observation group was treated with cerebrolysin and hyperbaric oxygen. The control group was treated with cerebrolysin The clinical efficacy and neurological recovery of the two groups were compared. Results: The markedly effective rate and total effective rate in the observation group were significantly higher than those in the control group (P <0.05). After one course of treatment, NBNA score of 28 days after birth in both groups was significantly higher than that before treatment, the difference was statistically significant (P <0.05). NBNA scores of the observation group after 1 course of treatment and after 28 days of birth were significantly higher than those of the control group at the same period. The difference between the two groups was statistically significant (P <0.05). Conclusion: Cerebrolysin combined with hyperbaric oxygen therapy for HIE can significantly improve the efficacy and promote the recovery of neurological function in neonates, which is worthy of clinical application.