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目的 观察冠状动脉粥样硬化影像表现与冠状动脉循环血浆内皮素 - 1( ET- 1)和一氧化氮 ( NO)水平的关系。方法 5 1例行冠状动脉造影者 ,造影前取血测定冠状静脉窦 ( CS)和冠状动脉开口 ( AO)血浆 ET- 1和 NO水平。冠状动脉腔径狭窄≥ 5 0 %者为严重冠状动脉病变组 ,反之为对照组。分析记录严重冠状动脉病变组病变血管数、狭窄病变数、闭塞病变数和病变范围积分。结果 1.严重冠状动脉病变组 CS血浆 ET- 1水平 ( ET- 1CS)和 CS与AO的差值 ( ET- 1CS- AO)明显高于对照组 ( P<0 .0 5 ) ;严重冠状动脉病变组 ET- 1CS明显高于 AO血浆 ET- 1水平( ET- 1AO) ( P<0 .0 5 )。 2 .严重冠状动脉病变组 NOCS和 NOCS- AO明显低于对照组 ( P<0 .0 5 ) ;严重冠状动脉病变组NOCS明显低于 NOAO( P<0 .0 5 )。 3 .严重冠状动脉病变组 ,ET- 1CS- AO与冠状动脉病变范围积分呈显著正相关 ( P<0 .0 5 ) ,NOCS- AO与冠状动脉病变范围积分呈显著负相关 ( P<0 .0 5 )。结论 冠状动脉粥样硬化影响冠状动脉循环血浆 ET- 1和 NO水平 ,粥样硬化病变范围与冠状动脉循环血浆 ET- 1和 NO水平有相关关系
Objective To observe the relationship between coronary atherosclerosis and plasma levels of endothelin - 1 (ET - 1) and nitric oxide (NO) in patients with coronary artery disease. Methods Fifteen patients with routine coronary angiography were enrolled. Blood samples were taken from the coronary sinus (CS) and the coronary artery (AO) to determine ET-1 and NO levels before angiography. Coronary artery stenosis ≥ 50% of patients with severe coronary lesions, whereas the control group. Analysis of severe coronary artery disease group records the number of vascular lesions, stenosis, occlusion lesions and pathological score. Results 1. The difference of ET-1CS level, CS-AO level (ET-1CS-AO) in severe coronary artery disease group was significantly higher than that in control group (P <0.05); severe coronary artery Lesion group ET-1CS was significantly higher than AO plasma ET-1 level (ET-1AO) (P <0.05). The levels of NO and NOCS-AO in patients with severe coronary artery disease were significantly lower than those in control group (P <0.05). The levels of NO in patients with severe coronary artery disease were significantly lower than those in patients with NOAO (P <0.05). There was a significant positive correlation between ET-1CS-AO and the extent of coronary artery disease (P <0.05) in the severe coronary artery disease group, and negative correlation between NOCS-AO and the coronary artery disease range (P <0.05). 0 5). Conclusions Coronary atherosclerosis affects plasma ET-1 and NO levels in coronary arteries, and the extent of atherosclerotic lesions correlates with plasma levels of ET-1 and NO in coronary arteries