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治疗血吸虫病新药78-02(300mg/kg)对麻醉猫心电图、心电向量图、心肌收缩性及血压调节无明显影响,仅少数动物心电图呈现轻度缺血。78-02(150mg/kg)对肾上腺素所致大白鼠心律失常的潜伏期、阈剂量和肾利尿与对照组相比无显著差异(P>0.05),但对肝功能有一定损害。
The new drug 78-02 (300mg/kg) for treating schistosomiasis had no significant effect on the electrocardiogram, electrocardiogram, myocardial contractility and blood pressure regulation of anesthetized cats. Only a few animals showed mild ischemia on the electrocardiogram. 78-02 (150mg/kg) had no significant difference in the latency, threshold dose and renal diuresis of arrhythmias-induced arrhythmia in rats compared with the control group (P>0.05), but had some damage to liver function.