免疫受损的癌肿患者对许多病原菌易感,因此,对这些患者需联合应用多种抗生素,研究最多的是氨基糖甙类抗生素加抗假单孢菌属青霉素。近来研究表明,青霉素与先锋霉素联用具有相同的作用,并可避免氨基糖甙类抗生素对肾脏的毒性。本文作者对近年来用β—内酰胺抗生素所致凝血异常和出血的发生率作了回顾。为了便于对不同抗生素联用进行估价而分以下几组:(1)18克苯咪唑青霉素/日和18克甲酰苄唑头孢菌素/日;(2)18克苯咪唑青霉素/日和12克甲酰苄唑 Immunocompromised cancer patients are susceptible to many pathogens. Therefore, a combination of multiple antibiotics is needed for these patients. The most studied are aminoglycoside antibiotics plus Pseudomonas penicillin. Recent studies have shown that penicillin and cephalosporin combined with the same effect, and to avoid aminoglycoside antibiotics on the kidney toxicity. The authors reviewed the incidence of clotting abnormalities and bleeding caused by β-lactam antibiotics in recent years. In order to facilitate the evaluation of the combination of different antibiotics, the following groups were divided: (1) 18 g benzimidazole penicillin / day and 18 g formylbenzamide cephalosporin / day; (2) 18 g benzimil penicillin / day and 12 Clofibrate