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目的探讨大肠埃希氏菌耐药性与抗生素用药频度之间的关系,为临床合理使用抗生素提供科学的参考依据。方法通过医院信息库药房管理系统对我院2006～2008年抗生素消耗做回顾性统计,采用限定日剂量(defined daily dose,DDD)法计算常用抗生素的用药频度(DDDS),根据当年的临床药敏试验结果,分析两者之间的相关性。结果左氧氟沙星的DDDS与大肠埃希氏菌对左氧氟沙星和环丙沙星的耐药率呈显著相关性。哌拉西林/他唑吧坦和替卡西林/克拉维酸以及头孢哌酮/舒巴坦的DDDS与大肠埃希氏菌对头孢哌酮的耐药率呈显著负相关性。头孢噻肟的DDDS与大肠埃希氏菌对头孢噻肟、头孢曲松、头孢唑林的耐药率呈显著相关性。结论大肠埃希氏菌是引起临床各类感染的重要病原菌之一,临床应结合药敏试验结果合理使用抗生素并采取有效措施控制耐药菌株的传播。
Objective To explore the relationship between the drug resistance of Escherichia coli and the frequency of antibiotic medication and to provide a scientific reference for the rational use of antibiotics in clinical practice. Methods Retrospective statistics on the antibiotic consumption in our hospital from 2006 to 2008 were conducted by using the pharmacy management system of hospital information database. DDDS was calculated by using defined daily dose (DDD) method. According to the current clinical drug Sensitivity test results, analysis of the correlation between the two. Results The DDDS of levofloxacin showed a significant correlation with the drug resistance rates of levofloxacin and ciprofloxacin in Escherichia coli. There was a significant negative correlation between DDDS of piperacillin / tazobactam and ticarcillin / clavulanic acid and cefoperazone / sulbactam and cefoperazone resistant rate of Escherichia coli. Cefotaxime DDDS and Escherichia coli on cefotaxime, ceftriaxone, cefazolin resistance rates were significantly correlated. Conclusion Escherichia coli is one of the most important pathogens causing various clinical infections. In clinical practice, antibiotics should be used in combination with antibiotic sensitivity test and effective measures should be taken to control the spread of drug-resistant strains.