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目的研究并分析梗阻性结直肠癌中E-cadherin、CD44v6的表达的临床病理意义。方法 2010年2月到2014年2月共计18例原发性梗阻性结直肠癌患者,其中男13例,女5例,平均年龄(67.3±5.9)岁。肿瘤Dukes分期:B期1例,C期14例,D期3例。另从研究所获得健康人结直肠癌福尔马林标本1例。免疫组化染色和评估的方法进行E-cadherin、CD44v6的表达的研究。结果在梗阻性结直肠癌不同的Dukes分期,E-cadherin的表达显著不同,D期已经是强阳性的结果;CD44v6的表达亦显著不同,B期是弱阳性结果,D期是强阳性的结果。结论E-cadherin和CD44v6在梗阻性结直肠癌患者中均可以检测到,且随着分期的不同表达量不同。在临床工作中可以采取用免疫组化检测E-cadherin和CD44v6方法避免漏检。
Objective To study and analyze the clinicopathological significance of the expression of E-cadherin and CD44v6 in obstructive colorectal cancer. Methods A total of 18 patients with primary obstructive colorectal cancer from February 2010 to February 2014 were enrolled, including 13 males and 5 females, with an average age of (67.3 ± 5.9) years. Tumor Dukes stage: B in 1 case, C in 14 cases, D in 3 cases. Another from the Institute of Health Colorectal cancer in 1 case of specimens. Immunohistochemical staining and assessment of the expression of E-cadherin, CD44v6. Results The expression of E-cadherin was significantly different in different Dukes stages of obstructive colorectal cancer. The D stage was already strongly positive; the expression of CD44v6 was also significantly different. The stage B was a weakly positive result and the stage D was strongly positive . Conclusions Both E-cadherin and CD44v6 can be detected in patients with obstructive colorectal cancer, and the expression of E-cadherin and CD44v6 varies with different stages. In clinical work can be taken by immunohistochemical detection of E-cadherin and CD44v6 method to avoid missed.