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目的探讨新疆维汉两民族帕金森病(PD)患者运动及非运动症状的严重程度。方法入选130例PD患者和80例健康人,通过完成临床症状评定量表评分(UPDRS)及Hoehn&Yahn(H-Y)评分,非运动症状评分量表,比较维汉两民族PD患者运动及非运动症状的差异性。结果维汉两民族PD患者在病程,起病年龄,UPDRSⅠ,Ⅱ,Ⅲ部分及H-Y分级及首发症状方面对比差异无统计学意义。腹胀、睡眠障碍、便秘、疲乏和排尿困难是最常见的非运动症状主诉,其发生率在维汉两民族PD所占比率分别为:38.75%vs 38%;37.5%vs 60%;41.25%vs 38%;32.5%vs 24%;35%vs 62%。维汉两民族PD患者在便秘及疲乏方面比较差异有统计学意义(P<0.05)。结论新疆维吾尔族PD患者在便秘及疲乏方面较汉族PD严重,而维汉两民族PD患者在其他运动症状及非运动症状方面比较无明显差异。
Objective To investigate the severity of motor and non-motor symptoms in patients with Parkinson’s disease (PD) in both Chinese and Uygur nationalities in Xinjiang Uygur Autonomous Region. Methods A total of 130 patients with PD and 80 healthy subjects were enrolled in this study. UPDRS, Hoehn & Yahn (HY) scores and non-motor symptom scores were compared to compare the motor and non-motor symptoms of PD patients difference. Results There was no significant difference in the course of disease, the age of onset, UPDRS Ⅰ, Ⅱ, Ⅲ, H-Y grade and the first symptom among PD patients of both ethnic groups. The incidence of abdominal distension, sleep disturbance, constipation, fatigue and dysuria were the most common non-motor symptoms. The incidence rate of PD in both Han and Wei Han nationality was 38.75% vs 38%, 37.5% vs 60%, 41.25% vs 38%; 32.5% vs 24%; 35% vs 62%. There was significant difference in constipation and fatigue between PD patients in both ethnic groups (P <0.05). Conclusion PD patients in Xinjiang Uygur have more severe constipation and fatigue than those in Han nationality. There is no significant difference in other motor symptoms and non-motor symptoms among PD patients in both ethnic groups.