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为了阐明微核试验用于察觉人类疾病中自发的染色体结构畸变是否是一种灵敏的试验,研究了10例恶性贫血患者的骨髓涂片和染色体标本。2男8女,年龄为36—84岁。另以10名非血液病患者(均未作过放射治疗或细胞静电药物治疗)作为对照。结果表明,在7例病人中至少有1个或1个以上的中期细胞含有结构畸变,畸变的类型主要是染色单体断裂,但也有数个染色体断裂。1个病例的几个中期细胞内为染色单体互换。对照组的结构畸变占中期细胞总数的1.2％,而贫血病人为5.0％。在10名病人中,8例见有微核,他们的
To clarify whether micronucleus test was used to detect spontaneous chromosomal structural aberrations in human disease was a sensitive test, bone marrow smears and chromosomal specimens of 10 patients with pernicious anemia were studied. 2 men and 8 women, aged 36-84 years old. In addition, 10 non-hematological patients (none of whom had radiotherapy or static drug treatment) were used as controls. The results showed that at least one or more of the seven metaphase cells contained structural aberrations, the type of aberrations mainly being chromatid breaks, but also several chromosomes ruptured. Several metaphase cells in 1 case are chromatid exchange. The structural aberrations in the control group accounted for 1.2% of the total number of metaphase cells, compared with 5.0% in anemic patients. Of the 10 patients, 8 had micronuclei, they were