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目的探讨新辅助化疗对宫颈癌的近期疗效。方法选择2000年2月-2008年10月在新洲区人民医院住院治疗,并行病理确诊的67例宫颈癌患者,采用5-FU联合DDP方案新辅助化疗1～2个疗程,观察近期疗效。结果临床近期有效率达83.6%,其中完全缓解15例(CR),部分缓解41例(PR)。化疗后肿瘤直径较化疗前有不同程度缩小。63例完成化疗后行广泛性子宫切除+盆腔淋巴结清扫术,4例化疗后行放疗。结论新辅助化疗可提高宫颈癌的近期疗效,为根治性手术和放疗创造条件,具有重要的临床意义。
Objective To investigate the short-term effect of neoadjuvant chemotherapy on cervical cancer. Methods From February 2000 to October 2008 in Xinzhou District People’s Hospital hospitalized 67 patients with pathologically confirmed cervical cancer using 5-FU combined with DDP regimen of neoadjuvant chemotherapy for 1 to 2 courses of treatment to observe the short-term efficacy. Results The clinical effective rate was 83.6%, of which 15 were completely relieved (CR) and 41 were partly relieved (PR). Tumor diameter after chemotherapy than before chemotherapy have reduced to varying degrees. Sixty-three patients underwent extensive hysterectomy and pelvic lymphadenectomy after chemotherapy, and radiotherapy was performed in 4 patients after chemotherapy. Conclusion Neoadjuvant chemotherapy can improve the short-term curative effect of cervical cancer and create conditions for radical surgery and radiotherapy. It has important clinical significance.