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目的:探讨凝血酶鼻饲治疗新生儿消化道出血的疗效。方法:78例新生儿消化道出血患儿随机分成2组,治疗组(n=36)在传统治疗的基础上采用鼻饲凝血酶,每次200U,每天2～3次,对照组静注vit K_1、止血敏,治疗后观察临床疗效,出血停止时间,同时观察不良反应。结果:治疗组总有效率94.44％,显著高于对照组(68.42％);治疗组出血控制时间(1.33±0.2)2d,较对照组(2.07±0.20)d明显缩短,未见不良反应。结论;凝血酶用于新生儿消化道出血的治疗安全有效。
Objective: To investigate the effect of thrombin nasal feeding on neonatal gastrointestinal bleeding. Methods: A total of 78 neonates with gastrointestinal bleeding were randomly divided into two groups. The treatment group (n = 36) received nasal thrombin on the basis of conventional therapy, 200 U per day for 2 to 3 times. The control group received intravenous vit K 1 , Hemostatic sensitivity, clinical efficacy after treatment, stop bleeding time, while observing adverse reactions. Results: The total effective rate of the treatment group was 94.44%, which was significantly higher than that of the control group (68.42%). The bleeding time of the treatment group was 1.33 ± 0.2 days, significantly shorter than that of the control group (2.07 ± 0.20) d with no adverse reactions. Conclusion; Thrombin is safe and effective for the treatment of neonatal gastrointestinal bleeding.