树突状细胞(DC)是目前已知的体内功能最强大的专职抗原递呈细胞,能诱导免疫应答的产生,同时在诱导移植免疫耐受调节中也起着重要的生物学作用。目前,DC诱导移植免疫耐受的作用已成为研究热点,并提出耐受性DC的概念。现就耐受性DC的体内迁移过程、体外获得以及在分子机制等方面进行综合分析,为进一步理解和研究耐受性DC在移植免疫反应中的作用奠定基础。 Dendritic cells (DCs) are currently the most potent professional antigen-presenting cells in the body that induce immune responses and play an important biological role in the regulation of immune tolerance induced by transplantation. At present, the role of DC in inducing transplant immune tolerance has become a research hotspot, and the concept of tolerogenic DC has been proposed. The process of in vivo migration of tolerogenic DCs in vitro, and in vitro molecular mechanisms were analyzed comprehensively, which laid the foundation for the further understanding and study of the role of tolerogenic DCs in transplantation immune response.