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目的探讨心衰患者的红细胞体积分布宽度与其血清N末端脑钠肽的相关性。方法选取两家医院2011年1月~2012年3月328例心衰确诊的住院患者的临床资料,采用自动全血细胞分析仪测量患者的红细胞体积分布宽度(RDW)和双向侧流免疫法测定心衰患者血清N末端脑钠肽(NT-proBNP),运用统计软件分析两者的相关性。结果根据红细胞体积分布宽度测量结果将心衰患者分为四组,其中Ⅰ组、Ⅱ组、Ⅲ组及Ⅳ组的NT-proBNP值分别为2 533pg/ml、5 061pg/ml、9 165pg/ml及14 434pg/ml,通过分析四组心衰患者的RDW水平与NT-proBNP浓度的关系,发现两者存在明显的相关性。结论心衰患者的RDW水平与NT-proBNP浓度存在明显的相关性,RDW水平在诊断心衰及判断预后时可作为NT-proBNP的有力补充。
Objective To investigate the correlation between the distribution width of erythrocyte and the serum N-terminal pro brain natriuretic peptide in patients with heart failure. Methods The clinical data of 328 hospitalized patients with heart failure diagnosed in two hospitals from January 2011 to March 2012 were selected. The width of erythrocytes volume distribution (RDW) and bilateral lateral flow immunoassay Serum N-terminal brain natriuretic peptide (NT-proBNP) was analyzed by using statistical software. Results The patients with heart failure were divided into four groups according to the measurement of the width distribution of erythrocytes. The NT-proBNP values of group Ⅰ, group Ⅱ, group Ⅲ and group Ⅳ were respectively 2 533 pg / ml, 5 061 pg / ml and 9 165 pg / ml And 14 434 pg / ml. There was a clear correlation between RDW levels and NT-proBNP concentrations in four groups of patients with heart failure. Conclusion There is a significant correlation between RDW level and NT-proBNP concentration in patients with heart failure. RDW level can be a powerful complement to NT-proBNP in the diagnosis of heart failure and prognosis.