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一种药物反复应用之后,突然停药或其作用被特殊拮抗剂阻断时,可出现严重的生理机能障碍,引起停药后的症状或停药后的危象,即为戒断综合征。戒断综合征的实质是生理上对此药的依赖性。急性的可在几小时内出现,慢性的可在较长时间方能表现出来。在临床用药中应当引起我们的警惕。下面仅就几种常见药物的戒断综合征予以综述。一、作用于心血管系统药物 1.心得安:心得安是最早应用于临床的β-受体阻滞药,临床应用比较广泛,主要用于抗心律失常,心绞痛和高血压,亦用于甲状腺机能亢进患者。尤其是对心绞痛为好。但是在临床应用中突然中断,可产生较严重的临床征象。表现交感神经过度兴奋的撤药症状,甲状腺机能亢进,快速心律失常,急性心肌梗塞、摔死。对心绞痛的病人,长期服用,一旦停药
A repeated application of a drug, a sudden withdrawal or its role is blocked by a special antagonist, there may be serious physiological dysfunction, causing withdrawal symptoms or withdrawal after the crisis, that is withdrawal syndrome. The essence of withdrawal syndrome is the physical dependence of the drug. Acute can occur in a few hours, chronic can be shown in a long time before. In clinical medication should arouse our vigilance. The following is a summary of several common withdrawal symptoms of drugs. First, the role of cardiovascular drugs 1 propranolol: propranolol is the earliest clinical application of β-blockers, clinical application is more extensive, mainly for anti-arrhythmia, angina pectoris and hypertension, also used in thyroid Functional hyperthyroidism patients. Especially for angina as well. However, sudden interruption in clinical application can produce more serious clinical signs. Symptoms of sympathetic hyperactivity withdrawal symptoms, hyperthyroidism, tachyarrhythmia, acute myocardial infarction, and death. For angina patients, long-term use, once the withdrawal