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目的探讨宫颈环形电切术(loop electrosurgical excision procedure,LEEP)与冷刀锥切术(cold knife conization,CKC)治疗宫颈上皮内瘤变(CIN)效果。方法计算机检索Pub Med、EMBASE、Cochrane Library、CBM、CNKI、万方数据库等方式收集相关文献。通过Revman 5.3软件对术中出血量、手术时间、切口愈合时间、术后出血等方面进行Meta分析。结果共纳入9篇文献,1 107例患者。两种术式在手术时间、术中出血、切口愈合、宫颈粘连及术后出血方面比较,差异有统计学意义(P<0.05)。在病理符合、CIN级别降低、切缘阳性、转移浸润方面无统计学差异(P>0.05)。结论 LEEP以其出血少,恢复快,价格低廉,操作简便等明显优势值得在临床推广应用。
Objective To investigate the effect of cervical electrosurgical excision procedure (LEEP) and cold knife conization (CKC) on cervical intraepithelial neoplasia (CIN). Methods PubMed, EMBASE, Cochrane Library, CBM, CNKI and Wanfang database were searched by computer. Meta-analysis was performed on the amount of intraoperative blood loss, operation time, incision healing time and postoperative bleeding through Revman 5.3 software. Results A total of 9 articles were included and 1,107 patients were included. There were significant differences between the two surgical procedures in operation time, intraoperative bleeding, incision healing, cervical adhesion and postoperative bleeding (P <0.05). There was no significant difference in pathology, CIN grade, positive margin and metastasis (P> 0.05). Conclusions LEEP with its less bleeding, rapid recovery, low prices, easy operation and other obvious advantages worthy of clinical application.