WHO(第四版)子宫肿瘤分类将子宫颈腺癌(ECA)分为“普通型”和“胃型”。由于两型ECA具有不同的免疫表型、HPV状态及预后,因此被认为具有不同的组织学起源。普通型ECA(U-ECA)几乎总是与高危型HPV(HR-HPV)感染有关,而胃型ECA(G-ECA)被认为与HR-HPV感染无关。形态学上,U-ECA细胞缺乏黏液、胞质嗜酸性,类似子宫内膜样癌。G-ECA细胞胞质丰富透明,内含黏液,细胞 WHO (fourth edition) classification of uterine cancer of the cervical adenocarcinoma (ECA) is divided into “ordinary type ” and “stomach type ”. Two types of ECAs are thought to have different histological origins because of their different immunophenotypes, HPV status and prognosis. Conventional ECA (U-ECA) is almost always associated with high-risk HPV (HR-HPV) infection, whereas gastric ECA (G-ECA) is considered unrelated to HR-HPV infection. Morphologically, U-ECA cells lack mucus, cytoplasmic acidosis, similar to endometrioid carcinoma. G-ECA cells rich and transparent cytoplasm, containing mucus, cells