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本实验采用四氧嘧啶选择性地损伤大鼠胰岛B细胞,制成糖尿病动物模型,观察异搏定对四氧嘧啶引起的大鼠糖尿病的预防作用。结果发现在给予四氧嘧啶前预防性注射异搏定能明显地预防四氧嘧啶引起的大鼠糖尿病,表现为异搏定加四氧嘧啶组在给予四氧嘧啶后48h的血糖值明显低于盐水加四氧嘧啶组。
In this experiment, alloxan was used to selectively injure rat islet B cells to establish a diabetic animal model and observe the preventive effect of verapamil on alloxan-induced diabetes in rats. The results showed that prophylactic injection of verapamil prior to administration of alloxan significantly prevented alloxan-induced diabetes in rats. The performance of verapamil plus alloxan was significantly lower than that of alloxan after 48 hours of administration of alloxan. Brine plus alloxan group.