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目的:探讨血管内皮生长因子(VEGF)在乳腺浸润性导管癌(IDC))组织中的表达及其与临床病理特征的关系。方法:采用SP免疫组化法检测72例IDC患者(IDC组)和30例乳腺纤维腺瘤(对照组)组织中VEGF的表达。结果:IDC组VEGF阳性表达率为68.1%,显著高于对照组(23.3%),两组相比较有显著性差异(P<0.05);VEGF阳性表达与IDC患者年龄和肿瘤直径大小无相关性,其阳性表达率差异无统计学意义(P>0.05);而VEGF水平与临床分期和病理组织学分级、以及肿瘤远处转移之间存在相关性,其阳性表达率有显著性差异(P<0.05)。结论:VEGF在IDC组织中呈高表达,VEGF参与了IDC发生发展和浸润转移,VEGF可以作为评价IDC恶性程度和淋巴结转移的一个新型指标。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in breast invasive ductal carcinoma (IDC) and its relationship with clinicopathological features. Methods: The expression of VEGF in 72 cases of IDC (IDC group) and 30 cases of breast fibroadenoma (control group) was detected by SP immunohistochemistry. Results: The positive rate of VEGF expression in IDC group was 68.1%, which was significantly higher than that in control group (23.3%), there was significant difference between the two groups (P <0.05). There was no correlation between the positive expression of VEGF and the age and tumor diameter (P> 0.05). However, there was a significant correlation between the level of VEGF and the clinical stage and pathological grade, as well as the distant metastasis of tumor. The positive rate of VEGF expression was significantly different (P < 0.05). CONCLUSION: VEGF is overexpressed in IDC tissues. VEGF is involved in the development, invasion and metastasis of IDC. VEGF may serve as a new marker for evaluating the malignancy and lymph node metastasis of IDC.