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糖皮质激素为临床常用药物，长期大剂量运用可引起内分泌系统功能紊乱及骨质疏松等严重不良反应“’。骨质疏松症目前是中、老年常见病、多发病”’，急需研制一些防治该类疾病的新药供临床应用，由于糖皮质激素作用随着剂量不同而异，故本文研究了氢化泼尼松诱导大鼠骨质疏松的模
Glucocorticoids are clinically used drugs, long-term use of large doses can cause endocrine system disorders and other serious adverse reactions such as osteoporosis. ’’ Osteoporosis is currently common in middle and old age, frequently-occurring disease, urgent need to develop Some of the new drugs for the prevention and treatment of such diseases for clinical use, because glucocorticoid effects vary with the dose, so this study of prednisolone-induced osteoporosis rat model