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药源性肝病是最常见的一种药源性疾病.国外药源性肝病发生率占住院病人的2%左右.精神病院和结核病院病人中肝损害率可高达20%以上.引起肝损害的药物约600种,几乎遍及各类药物.病理改变有肝细胞病变,胆汁郁积,肝血管损害和肝肿瘤.药物性肝病按发病过程可分为急性和慢性两类.按损害的机理有直接损害肝实质细胞及过敏性反应,前者与用药剂量密切相关,后者发病率低与用药剂量无直接相关,且伴有其它致敏表现.临床医师在选择用药时,尤其选用对肝脏有直接损害作用的药物时,应严格控制用药量和用药期限,并随时注意肝功能改变,以决定是否继续用药、减量或停药.
Drug-induced liver disease is one of the most common drug-induced diseases. The incidence of drug-induced liver disease in foreign countries accounted for about 2% of patients in hospital mental hospital and tuberculosis patients liver damage rate can be as high as 20% or more. About 600 kinds of drugs, almost all kinds of drugs. Pathological changes have hepatocellular disease, cholestasis, hepatic vascular injury and liver tumors. According to the pathogenesis of drug-induced liver disease can be divided into two categories of acute and chronic. According to the mechanism of damage has direct damage Liver parenchymal cells and allergic reactions, the former is closely related with the dosage, the latter with low incidence and dosage is not directly related to, and accompanied by other sensitization performance.Collectors in the choice of medication, especially the choice of direct damage to the liver Of the drugs, should strictly control the dosage and duration of medication, and keep an eye on changes in liver function, to decide whether to continue medication, reduction or withdrawal.