本文报告甲基钴胺素肌注治疗41例糖尿病性神经障碍的效果。 41例均有麻木感、自发性疼痛、感觉异常、知觉迟钝而麻木等。其中饮食疗法15例,口服药物治疗4例,胰岛素治疗22例。饮食疗法者67%病程在5年以内,胰岛素治疗者大多在10年以上。甲基钴胺素每2天肌注500μg(IA),平均用药2.5个月。结果:病程对甲基钴胺素的疗效无明显影响。总有效率为80%,饮食疗法组81.5%,口服药物组77.8%,胰岛素治疗组79.1%,3组无明显差异。肌注甲基钴胺素后上述症状改善迅速(1～2周)。已有报告口服甲基钴胺素对改善糖尿病性神经障碍有效,一般需时4～8周,此时腱反射、振动觉、运动神经传导速度等也见改善。而采用每2天肌注甲 This article reports the effect of methylcobalamin in the treatment of 41 cases of diabetic neuropathy. 41 cases were numbness, spontaneous pain, sensory abnormalities, sensory retardation and numbness. There were 15 cases of diet therapy, 4 cases of oral medication and 22 cases of insulin therapy. Diet therapy 67% course of disease in less than 5 years, mostly insulin treatment in more than 10 years. Methylcobalamin was injected intramuscularly 500 μg (IA) every 2 days for an average of 2.5 months. Results: The duration of the effect of methylcobalamin no significant effect. The total effective rate was 80%, dietary therapy group 81.5%, oral drug group 77.8%, insulin treatment group 79.1%, 3 groups no significant difference. After intramuscular injection of methylcobalamin the above symptoms improved rapidly (1 to 2 weeks). Oral methylcobalamin has been reported to be effective in improving diabetic neuropathy, which normally takes 4 to 8 weeks, at which time the tendon reflex, the vibrational sensation, the motor nerve conduction velocity and the like are also improved. The use of intramuscular injection every 2 days