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为了解白细胞介素 - 8的体内行为 ,用 Bolton- Hunter法对 IL- 8进行 1 2 5I标记 ,并测定它在小鼠体内的分布 ;得到了 1 2 5I- IL- 8在小鼠血、心、肝、肺、肾、骨、脾等脏器中的分布以及它在血液中的快相半排期 T1 /2α为 0 .3 2 h和慢相半排期 T1 /2β为 8.0 1h。1 2 5I- IL- 8主要通过肾排除
In order to understand the in vivo behavior of interleukin-8, IL-8 was labeled with 125 I using Bolton-Hunter method and its distribution in mice was determined. The results showed that IL- The distribution of heart, liver, lung, kidney, bone, spleen and other organs and its fast half-phase T1 / 2α in blood was 0.32 h and the half-life T1 / 2 β was 8.0 1 h. 1 2 5I-IL-8 is mainly eliminated by the kidneys