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本文报道急性疟疾感染期间人血小板分泌活动的改变。实验分为疟疾患者和正常对照两组进行。患者年龄为0.5～35岁,对照组为17～20岁的健康青少年和成年自愿供血者。由于该年龄范围内性别和年龄因素对所检测指标无影响,因而没有匹配年龄和性别的对照,此外尚以其它原因发热的少数患者为对照。测定的血小板分泌参数及受检人数如下:(1)用放射免疫法测定血小板特殊蛋白质的分泌:包括β-血小板球蛋白(患者25例,对照17名),血小板第4因子(患者20例,对照7名);(2)~(14)C标记的5羟色胺(5HT)的摄取(患者14例,对照37名)和释放(患者20例,对照25名);(3)经凝血酶刺激后,血小板中乳酸
This article reports the changes in human platelet secretion during acute malaria infection. The experiment was divided into two groups: malaria patients and normal controls. Patients aged 0.5 to 35 years, control group of 17 to 20-year-old healthy adolescents and adult voluntary blood donors. Because gender and age factors within this age range had no effect on the indicators tested, there were no controls that matched age and gender, and a minority of patients who were otherwise experiencing fever. The measured platelet secretion parameters and the number of subjects were as follows: (1) Determination of platelet specific protein secretion by radioimmunoassay: β-thromboglobulin (25 patients, control 17), Platelet factor 4 (20 patients, (2) 14C-labeled serotonin (5HT) uptake in 14 patients (control group, 37 patients) and release (20 patients in the control group, 25 controls); (3) stimulation with thrombin After lactic acid in platelets