本文应用免疫组织化学PAP法,对硫脉致甲状腺功能低下(甲低)小鼠胃窦粘膜5—羟色胺及生长抑素样免疫反应细胞,进行免疫组织化学染色。结果发现:甲低时胃窦部5—羟色胺细胞数目减少(P<0.01),染色变浅,形态无明显变化。而生长抑素免疫反应细胞数目有增加趋势。此结果提示:甲状腺素可影响胃窦粘膜EC细胞中5—羟色胺的合成。 Immunohistochemical PAP method was used to detect the serotonergic and somatostatin-like immunoreactive cells in the gastric antral mucosa of hypothyroid mice with hypothyroidism. The results showed that the number of antral serotoninergic cells in hypothyroidism decreased (P <0.01), the staining became lighter and the morphology did not change significantly. The somatostatin immune response cells have an increasing trend. This result suggests that thyroxine may affect serotonin synthesis in antral gastric mucosal EC cells.