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现已初步证实,肿瘤细胞染色体DNA失衡是胶质瘤发生、发展的重要因素,而胶质瘤的个体化差异是其染色体DNA失衡类型不同的结果。不同类型胶质瘤特异性染色体DNA失衡变异谱的研究,对寻找与其发生、发展密切相关的关键责任基因,制定其分子遗传学分类新标准,设计合理有效的个体化治疗方案及评估患者预后均具有重要的实用价值。比较基因组杂交技术的建立和研究发现,为进一步探讨胶质瘤染色体DNA失衡提供了有用的技术手段。
It has been initially confirmed that the imbalance of chromosomal DNA in tumor cells is an important factor in the occurrence and development of gliomas, and the individual differences of gliomas are the result of different types of chromosomal DNA imbalances. The study of different types of glioma-specific chromosomal DNA imbalance in the study of the key genes responsible for its occurrence and development, to develop a new standard of molecular genetics to design a reasonable and effective individualized treatment programs and to assess the prognosis of patients Has important practical value. The establishment of comparative genomic hybridization technology and research found that, to further explore the glioma chromosomal DNA imbalance provides a useful technical means.