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目的:对湖州地区无偿献血人群感染丙肝的危险因素进行分析。方法:对无偿献血中ELISA检测抗-HCV阳性标本再进行RIBA和PCR确认,收集确认阳性献血者与HCV感染相关危险因素的信息,进行1∶2配对设计的条件logistic回归分析。结果:135 653名献血者中,有114例被确认为阳性,流行率为(0.084±0.004)%,并且随着年龄增长流行率越高,男性高于女性;与HCV感染相关的危险因素有共用剃刀(OR=15.08;95%CI:5.75~39.53)、住院史(OR=6.43;95%CI:2.56~16.14)、输血史(OR=11.67;95%CI:2.50~54.43)、共用玻璃注射器(OR=5.51;95%CI:2.38~12.77)以及家族肝炎史(OR=11.46;95%CI:3.22~40.85)等行为有关。结论:湖州地区无偿献血人群HCV感染率较低,加强医院感染控制,规范美容行业,以及普及公众的防范意识,将会有效降低HCV的感染。
Objective: To analyze the risk factors of hepatitis C infection in blood donors in Huzhou area. Methods: The anti-HCV positive samples detected by ELISA in unpaid blood donors were further confirmed by RIBA and PCR. The information of risk factors related to HCV infection was collected and confirmed by conditional logistic regression analysis. Results: Of the 135 653 blood donors, 114 were confirmed as positive and the prevalence was (0.084 ± 0.004)%, and the prevalence rate was higher in males than females with age; the risk factors associated with HCV infection were (OR = 15.08; 95% CI: 5.75-39.53), hospitalization history (OR = 6.43; 95% CI: 2.56-16.14), history of blood transfusion (OR = 11.67; 95% CI: 2.50-54.43) (OR = 5.51; 95% CI: 2.38-12.77) and family history of hepatitis (OR = 11.46; 95% CI: 3.22-40.85). Conclusion: The HCV infection rate in the blood donors in Huzhou area is relatively low. Enhancing the control of nosocomial infection, standardizing the beauty industry and popularizing public awareness of prevention will effectively reduce the infection of HCV.