培氟沙星(氧氟哌酸、甲氟哌酸、PFLX)是第三代氟喹诺酮类抗菌药,具有广谱抗菌作用,本品为杀菌剂,其作用机理为抑制DNA螺旋酶。本文将此药与其它药物在临床的应用报道如下:1 与H_2受体阻断剂合用 西米替丁可减缓培氟沙星的排泄,二者合用后,临床观察发现,培氟沙星的AUC升高35％,半衰期 Pefloxacin (oxfloxacin, norfloxacin, PFLX) is the third generation of fluoroquinolone antibacterial drugs, with broad-spectrum antibacterial effect, the product is a fungicide, its mechanism of action is to inhibit DNA helicase. In this paper, the drug and other drugs reported in clinical applications are as follows: 1 and H 2 receptor blocker cimetidine can slow the excretion of pefloxacin, the two combined, the clinical observation found that pefloxacin AUC increased by 35%, half-life