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众所周知,妇女生育力在30岁以后下降,35岁以后明显下降,45岁以后几乎丧失。此外,30岁后早期妊娠流产率大幅度增加,40岁以后超过50％。为证实高龄妇女生育力下降的原因是卵母细胞质量差还是子宫/子宫内膜机能不全,对35例40岁以上(平均42.7岁)妇女进行前瞻性研究。这些妇女排卵周期正常,至少有3年不育史,并排除了其配偶无生育力的可能性。收集病人自身卵子和29例行体外受精(IVF)的年轻妇女(平均33.4岁)捐献的卵母细胞,分别在IVF后移植于病人子宫内。
It is well-known that the fertility of women declines after the age of 30, decreases significantly after the age of 35 and is almost lost after the age of 45. In addition, miscarriage rates increased significantly in early pregnancy after age 30 and exceeded 50% after 40 years of age. To confirm the decline in fertility in older women due to poor oocyte or uterine / endometrial insufficiency, a prospective study of 35 women over the age of 40 (mean, 42.7 years) was performed. These women have normal ovulation cycles with a history of infertility of at least 3 years and exclude the possibility that their spouse will have no fertility. The oocytes donated by the patient’s own egg and 29 young women (mean 33.4 years) undergoing in vitro fertilization (IVF) were collected and transplanted into the uterus of the patient after IVF respectively.