一氧化氮合成酶仔在于脑组织的各个部位,以小脑中含量最丰,并与神经元结合.其纯品已从大脑、小脑中提取,系一种含FAO、FMN和非卟啉铁的蛋白质.在Ca_(2+)、钙调素、NADPH存在时,催化脑组织的L—精氨酸转变为L—瓜氨酸及一氧化氮.此酶需四氢生物蝶呤为辅因子,巨噬细胞中有不依赖Ca_(2+)、钙调素的一氧化氮合成酶,也需NADPH和氢 Nitric oxide synthase is found in all parts of the brain, most abundant in the cerebellum, and binds to neurons. Its pure product has been extracted from the brain and cerebellum and is derived from the brain, including the FMN and non-porphyrin iron Protein in the presence of Ca2 +, calmodulin, NADPH, the catalytic L-arginine brain tissue into L-citrulline and nitric oxide, this enzyme requires tetrahydrobiopterin as a cofactor, Macrophages have Ca2 +, calmodulin-independent nitric oxide synthase, but also NADPH and hydrogen