呼吸机相关性肺损伤(Ventilator-associated lung injury,VILI)是机械通气引起的严重并发症,目前临床上仍然缺乏完全有效的治疗策略。随着对VILI发病机制的不断深入研究,Toll样受体依赖的信号转导通路被认为参与了VILI的发生发展。Toll样受体识别相关配体后,通过启动细胞内外信号级联反应,介导肺部炎性因子的释放及释放后的病理生理改变。深入研究Toll样受体在VILI中的作用,可为临床提供参考。 Ventilator-associated lung injury (VILI) is a serious complication caused by mechanical ventilation. Currently, there is still a lack of a completely effective treatment strategy in clinic. With the further study of the pathogenesis of VILI, Toll-like receptor-dependent signal transduction pathway is considered to be involved in the development of VILI. Toll-like receptors mediate the release of pulmonary inflammatory cytokines and the pathophysiological changes after their release through the activation of intracellular and extracellular signaling cascades. In-depth study of Toll-like receptors in VILI role, can provide a reference for clinical.