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我们测定了70例不同肝功能状态的乙肝后肝硬化患者的血浆内皮素(ET)、心钠素(ANF)、肾素活性(PRA)、血管紧张素(ATⅡ),以观察其改变规律并探讨了ANF、ET、PRA、ATⅡ之间的关系。 对象和方法 一、对象:住院经病史询问、体检、血液生化、B超、CT等检查确诊的乙型肝炎后肝硬化70例(男52,女18),年龄24.5～72岁,平均50岁。按Child分级A级18例,B级32例,C级20例,所有患者均无心血管病、肾脏病史,入选时无上消化道出血,血清Cr、BUN属正常范围。对照组选择健康人30例(男20,女10),年龄25～69岁,平均48岁。 二、方法: (一)标本采集:肝硬化组,予低盐饮食(NaCl<3g/d),限水、腹水者停利尿剂5天后,于晨安静状
We measured plasma endothelin (ET), atrial natriuretic peptide (ANF), renin activity (PRA) and angiotensin (ATⅡ) in 70 patients with posthepatitic cirrhosis with different liver function status, Explore the relationship between ANF, ET, PRA, AT Ⅱ. Subjects and Methods 1. Subjects: 70 cases of post-hepatitis B cirrhosis confirmed by medical history, blood tests, blood biochemistry, B-ultrasound and CT examination (age 52 and 18), aged from 24.5 to 72 years (average 50 years) . According to Child’s classification, there were 18 cases of A grade, 32 cases of B grade and 20 cases of C grade. All patients had no history of cardiovascular disease and kidney disease. No upper gastrointestinal bleeding was found at the time of selection. Serum Cr and BUN were normal range. Control group, 30 healthy people (20 men and 10 women), aged 25 to 69 years, mean 48 years. Second, the method: (a) specimen collection: cirrhosis group, low salt diet (NaCl <3g / d), water restriction, ascites stopped diuretic 5 days,