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目的探讨唑来膦酸注射液对于2型糖尿病患者骨质疏松的临床治疗效果。方法将入住该院的48例2型糖尿病合并骨质疏松患者作为研究对象,给予唑来膦酸注射液开展治疗,在1年后,对比患者在治疗前后腰椎L1~L4、股骨大转子、股骨颈、华氏三角区的骨密度情况;实验室检查对比血钙、血磷、骨特异性碱性磷酸酶和骨钙素情况;对患者治疗前后的疼痛评分进行对比。结果患者在接受唑来膦酸注射液联合碳酸钙治疗1年后,腰椎L1~L4、股骨大转子、股骨颈、华氏三角区骨密度情况较治疗前显著改善,差异有统计学意义(P<0.05);患者在1年后骨钙素及血钙情况显著升高,差异有统计学意义(P<0.05);骨特异性碱性磷酸酶较1年前显著降低,差异有统计学意义(P=0.03);患者由于骨质疏松出现的骨痛情况显著改善,差异有统计学意义(P<0.05)。结论给予2型糖尿病合并骨质疏松病人唑来膦酸注射液,临床效果较好,可以在临床中推广应用。
Objective To investigate the clinical effect of zoledronic acid injection on type 2 diabetic patients with osteoporosis. Methods Forty-eight patients with type 2 diabetes mellitus and osteoporosis admitted to our hospital were enrolled and treated with zoledronic acid injection. One year later, the patients with lumbar vertebra L1 ~ L4, femoral greater trochanter, femur Neck, Fahrenheit triangle bone mineral density; laboratory tests comparing serum calcium, phosphorus, bone specific alkaline phosphatase and osteocalcin; before and after treatment of patients with pain scores were compared. Results The BMD of lumbar vertebrae L1 ~ L4, femoral trochanter, femoral neck and Fahrenheit triangle were significantly improved after 1 year of treatment with zoledronic acid injection and calcium carbonate (P < 0.05). The level of osteocalcin and serum calcium were significantly increased in patients one year later (P <0.05). The bone specific alkaline phosphatase was significantly lower than that of one year ago, with significant difference (P < P = 0.03). Patients with bone pain due to osteoporosis significantly improved, the difference was statistically significant (P <0.05). Conclusions Zoledronic acid injection for patients with type 2 diabetes mellitus and osteoporosis has better clinical effect and can be widely applied in clinic.