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Objective: To investigate the diagnosis and treatment of invasive fungal infections (IFI) in the patients admitted to the Department of Obstetrics and Gynecology in Peking Union Medical College Hospital (PUMCH).Methods: The IFI data from the clinical laboratory and medical records of PUMCH from January, 2003 to December, 2009 were studied retrospectively. The patients were classified by diagnostic criteria as confirmed, clinical-diagnosed or suspected cases, and classified by treatment protocols into surgery, chemotherapy or end-stage of malignant tumors. The distribution, pathogens, risk factors and treatment outcomes of IFIs in these patients were discussed.Results: The data of 220 obstetric-gynecologic cases of IFIs were retrieved (52 cases confirmed, 11 clinical-diagnosed and 157 suspected). The incidence of confirmed urinogenital IFIs in obstetric-gynecologic patients was greater than overall incidence of urinogenital IFIs in PUMCH (46.2% vs. 18.7%, P