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目的 观察EB病毒 (EBV)重叠感染是否与乙型丙型肝炎病程迁延有关。方法 观察 16例慢性乙型丙型肝炎重叠EB病毒感染患者 (观察组 )肝功能持续异常时间 (病程 ) ,并以同期住院的 16例无合并EBV感染的慢性乙型丙型肝炎患者作对照组。结果 两组症状、血象相仿 ,观察组病程 (2 0 3 19± 16 8 2 9)d ,明显长于对照组 (6 4 6 3± 5 6 6 2 )d ,差异非常显著 (P <0 0 1) ;另选 4例乙型肝炎重叠EBV感染者试行抗病毒治疗 ,2例以苦参素治疗者肝功能复常时间是半年、7月 ,另 2例以拉米呋啶治疗者肝功能复常时间为 15d、2 5d。结论 乙型丙型肝炎重叠EBV感染确是其病程迁延的原因之一 ,拉米呋啶治疗可能会缩短患者病程
Objective To observe whether Epstein-Barr virus (EBV) overlap infection is associated with the duration of hepatitis B disease. Methods Sixteen patients with chronic hepatitis B overlap EBV infection (observation group) were observed for the duration of abnormal liver function (duration). Sixteen patients with chronic hepatitis B without EBV infection were enrolled as control group . Results The symptoms of the two groups were similar. The duration of the observation group (2033 19 ± 16 8 2 9) d was significantly longer than that of the control group (64 46 ± 56 6 2) d, with significant difference (P 0 01 ); Another 4 cases of hepatitis B overlap EBV infection trial of antiviral therapy, 2 cases of oxytocin treatment of liver function time is half a year, July, the other 2 cases of lamivudine treatment of liver function complex Often 15d, 25d. Conclusions Overlapping EBV infection with hepatitis B is indeed one of the reasons for the prolonged course of the disease. Lamivudine may shorten the course of the disease