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目的 :了解改良丁丙诺啡方法对海洛因依赖者戒毒的疗效。 方法 :对海洛因依赖者戒毒治疗的病人 90例分为 2组 ,A组以氯氮平、氯羟安定治疗 ;B组以氯氮平、氯羟安定联用丁丙诺啡治疗。比较两组的疗效、戒断症状及药物副作用的差异。 结果 :两种治疗方案对海洛因依赖者戒毒治疗均有效 ,但改良丁丙诺啡组患者戒断症状轻 ,用药量较小 ,两组间有显著性差异。 结论 :改良丁丙诺啡组对戒断症状的控制优于单独使用氯氮平和氯羟安定组 ,治疗安全性更大 ,病人也较易管理
Objective: To understand the effect of modified buprenorphine on detoxification of heroin addicts. Methods: Ninety patients with heroin addicts were divided into two groups. Patients in group A were treated with clozapine and lorazepam. Patients in group B were treated with clozapine and lorazepam. The curative effect, withdrawal symptoms and drug side effects were compared between the two groups. Results: Both treatment regimens were effective in detoxification of heroin addicts. However, patients in the modified buprenorphine group had less withdrawal symptoms and less dosage, with significant differences between the two groups. CONCLUSION: The modified buprenorphine group is superior to clozapine and chlorpromazine alone in the control of withdrawal symptoms, with greater safety and patient management