论文部分内容阅读
颅面痛严重影响患者的生活质量,已成为社会经济的负担。三叉神经节(TG)在颅面痛的发生过程中起着重要作用。颅面部的感觉信息通过TG传到脑干,脑干再将信息投射到更高级的大脑皮层进行编码。谷氨酸神经递质参与颅面痛的外周敏化机制,对颅面痛的产生和维持有重要作用。谷氨酸受体包括离子型(iGluRs)和代谢型(mGluRs)两种。目前尚缺乏mGluR在TG的神经元和卫星胶质细胞(SGC)中表达的研究。本研究对6只成熟的雄性Wistar大鼠的TG进行免疫组化和免疫细胞化学染色,进而观察不同
Craniostatics seriously affect the quality of life of patients, has become a socio-economic burden. Trigeminal ganglia (TG) play an important role in the development of craniofacial pain. The sensory information of the craniofacial area is transmitted to the brainstem via TG, which then projects the information to a higher level of the cerebral cortex for coding. Glutamate neurotransmitters participate in the peripheral sensitization mechanism of craniofacial pain, which plays an important role in the production and maintenance of craniofacial pain. Glutamate receptors include both iGluRs and mGluRs. Currently there is a lack of research on the expression of mGluR in TG neurons and satellite glial cells (SGC). In this study, the TG of 6 mature male Wistar rats was immunohistochemically and immunocytochemically stained to observe the difference